牛丽亚  

教授，博士生导师，理学博士 

教育部“长江学者奖励计划”青年学者

通信地址：北京市新街口外大街19号美加墨世界杯官方网站918A     

邮编：100875

电话：010 5880 6828   

电子邮箱：niuly@bnu.edu.cn    

研究兴趣

氧化还原荧光探针与诊疗试剂；活性氧调控分子机制；光催化邻近标记

课题组主页：https://www.x-mol.com/groups/qingzheng_yang

学习工作经历

2016.04–至今：美加墨世界杯官网，美加墨世界杯官方网站，讲师、副教授、教授

2013.07–2016.03：中国科学院理化技术研究所，助理研究员

2010.09– 2013.06：中国科学院理化技术研究所，博士（导师: 杨清正）

2007.09– 2010.03：北京航空航天大学化学与环境学院，硕士 （导师: 郭林、张东凤）

2003.09– 2007.06：北京航空航天大学材料科学与工程学院，学士

代表性论文

1. Kun-Xu Teng, Dongsheng Zhang, Bin-Kai Liu, Zheng-Fei Liu, Li-Ya Niu* and Qing-Zheng Yang*, Photo-Induced Disproportionation-Mediated Photodynamic Therapy: Simultaneous Oxidation of Tetrahydrobiopterin and Generation of Superoxide Radicals, Angew. Chem. Int. Ed. 2024, 63, e202318783

2. Kun-Xu Teng, Li-Ya Niu* and Qing-Zheng Yang*, Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy, J. Am. Chem. Soc. 2023, 145, 4081-4087.

3. Dongsheng Zhang, Kun-Xu Teng, Luyang Zhao, Li-Ya Niu* and Qing-Zheng Yang*, Ultra-small Nano-assemblies as Tumor-targeted and Renal Clearable Theranostic Agent for Photodynamic Therapy, Adv. Mater. 2023, 35, 2209789. 

4. Dongsheng Zhang, Kun-Xu Teng, Na Shao, Li-Ya Niu* and Qing-Zheng Yang*, Cascade Responsive Photosensitizer for Precise Delivery and Photodynamic Therapy, J. Med. Chem. 2025, 68, 8648–8658.

5. Yan-Fei Kang, Wen-Kai Chen, Kun-Xu Teng, Ling-Yun Wang, Xiao-Cheng Xu, Li-Ya Niu,* Ganglong Cui* and Qing-Zheng Yang*, Aggregation turns BODIPY fluorophores into photosensitizers: reversibly switching intersystem crossing on-and-off for smart photodynamic therapy, CCS Chem, 2022, 4, 3516-3528.

6. Xiao-Xiao Chen, Li-Ya Niu* and Qing-Zheng Yang*, Visualizing the Underlying Signaling Pathway Related to Nitric Oxide and Glutathione in Cardiovascular Disease Therapy by a Sequentially Activated Fluorescent Probe, Anal. Chem., 2021, 93, 3922-3928.

7. Kun-Xu Teng, Li-Ya Niu,* Yan-Fei Kang, and Qing-Zheng Yang,* Rational Design of a “Dual Lock-and-Key” Supramolecular Photosensitizer Based on Aromatic Nucleophilic Substitution for Specific and Enhanced Photodynamic Therapy, Chem. Sci., 2020, 11, 9703–9711.

8. Xin Zhu, Jian-Xin Wang, Li-Ya Niu,* Qing-Zheng Yang*, Aggregation-Induced Emission Materials with Narrowed Emission Band by Light-Harvesting Strategy: Fluorescence and Chemiluminescence Imaging, Chem. Mater. 2019, 31, ‏ 3573-358.

9. Xiao-Xiao Chen, Li-Ya Niu,* Qing-Zheng Yang*, BODIPY-Based Fluorescent Probe for Dual-Channel Detection of Nitric Oxide and Glutathione: Visualization of Cross-Talk in Living Cells, Anal. Chem. 2019, 91, 4301−4306.

10. Li-Ya Niu, Yu-Zhe Chen, Hai-Rong Zheng, Li-Zhu Wu, Chen-Ho Tung and Qing-Zheng Yang*, Design Strategies of Fluorescent Probes for Selective Detection Among Biothiols, Chem. Soc. Rev. 2015, 44, 6143-6160.

11. Li-Ya Niu, Ying-Shi Guan, Yu-Zhe Chen, Li-Zhu Wu, Chen-Ho Tung and Qing-Zheng Yang* BODIPY-Based Ratiometric Fluorescent Sensor for Highly Selective Detection of Glutathione over Cysteine and Homocysteine J. Am. Chem. Soc. 2012, 134, 18928−18931.