刘洋

教授，博士生导师

通信地址：北京市海淀区新街口外大街19号美加墨世界杯官方网站

邮政编码：100875

电子邮箱：yangliu@bnu.edu.cn

学习和工作经历

2026-至今，美加墨世界杯官网, 美加墨世界杯官方网站, 教授

2022-2026年，新加坡南洋理工大学，化学化工与生物技术学院，博士后研究员（合作导师：赵彦利 院士）

2021-2022年，中国科学经理春应用化学研究所，研究助理（导师：张洪杰 院士）

2016-2021年，中国科学技术大学，应用化学与工程学院（中国科学经理春应用化学研究所），博士（导师：张洪杰 院士）

2012-2016年，黑龙江大学，本科

研究领域

功能纳米材料化学；纳米催化医学；活体分析化学

研究兴趣

本课题组聚焦于生物医用纳米材料的设计及其生物医学应用研究，致力于解决国家重大健康相关科学问题。主要研究兴趣包括：类酶催化，框架材料设计与制备，纳米催化医学、生物成像与生物传感、癌症诊断与治疗、脑化学信号检测与调控，以及皮肤健康与组织修复等。

奖励与荣誉

2025 国家级高层次人才青年项目

2025 吉林省自然科学二等奖（3/5）

2021 中国科学技术大学优秀毕业生，中国科学技术大学优秀毕业论文提名

2020 中国科学院经理优秀奖

招生情况

欢迎热爱科研、认真踏实、具有团队精神的同学加入课题组：每年招收博士生1-2名、硕士生1-2名。优先欢迎具有化学、材料、生物医学等相关背景的同学；同时欢迎本科生加入课题组参与科研训练和毕业设计。课题组也长期招聘博士后研究员，尤其欢迎具有化学/材料合成、纳米生物学、脑科学或神经科学相关研究背景的优秀人才加盟。

代表性研究成果

1. Yang Liu†, Rui Niu†, Yinghui Wang, Hongjie Zhang, Yanli Zhao*, Preparation and biomedical applications of single-metal atom catalysts, Nat. Protoc. 2026. 21, 775-807.

2. Yang Liu†, Huan Zhao†, Rui Niu, Bin Zhang, Boon Teck Garrick Lim, Shuyan Song, Yinghui Wang*, Hongjie Zhang*, Yanli Zhao*, Single-site nanozyme with exposed unsaturated Cu-O2 sites for tumor therapy by coordinating innate immunity and vasculature normalization, Chem, 2025, 11, 102297. (ESI高被引论文)

3. Yang Liu, Huan Zhao, Rui Niu, Bin Zhang, Shuai Bi, Shuyan Song, Yinghui Wang*, Hongjie Zhang*, Yanli Zhao*, Defective single-site nanozymes with exposed unsaturated Cu-N2 sites for antitumor immunotherapy via innate immune-checkpoint blockade. J. Am. Chem. Soc. 2026, 148, 9277-9295.

4. Yang Liu, Huan Zhao, Shihuai Wang*, Rui Niu, Shuai Bi, Wangkang Han, Yinghui Wang, Shuyan Song, Hongjie Zhang*, Yanli Zhao*, A Wurster-type covalent organic framework with internal electron transfer-enhanced catalytic capacity for tumor therapy, J. Am. Chem. Soc. 2024, 146, 27345−27361.

5. Yang Liu, Rui Niu, Huan Zhao, Yinghui Wang*, Shuyan Song, Hongjie Zhang*, Yanli Zhao*, Single-site nanozymes with a highly conjugated coordination structure for antitumor immunotherapy via cuproptosis and cascade-enhanced T lymphocyte activity, J. Am. Chem. Soc. 2024, 146, 3675−3688. (ESI高被引论文)

6. Yang Liu†, Rui Niu†, Ruiping Deng, Shuyan Song, Yinghui Wang*, Hongjie Zhang, Multi-enzyme Co-expressed dual-atom nanozymes induce cascade immunogenic ferroptosis via activating interferon-γ and targeting arachidonic acid metabolism, J. Am. Chem. Soc. 2023, 145, 8965−8978. (ESI高被引论文)

7. Yang Liu, Wenyao Zhen, Yinghui Wang*, Shuyan Song, Hongjie Zhang*, Na2S2O8 nanoparticles trigger antitumor immunotherapy through reactive oxygen species storm and surge of tumor osmolarity, J. Am. Chem. Soc. 2020, 142, 21751−21757.

8. Rui Niu, Yang Liu*, Bin Zhang, Bo Xu, Zhijia Lv, Ruiping Deng, Shuyan Song, Kai Liu, Yinghui Wang*, Hongjie Zhang*, Charge-tunable dense dual-atom nanozymes reprogram biothiol metabolism through multi-enzyme-mimetic catalysis to synergistically induce frroptosis and disulfidptosis, Angew. Chem. Inter. Ed. 2026, e24634.

9. Yang Liu†, Huan Zhao†, Yanli Zhao*, Designing efficient single metal atom biocatalysts at the atomic structure level, Angew. Chem. Inter. Ed. 2024, 63, e202315933.

10. Yang Liu†, Rui Niu†, Ruiping Deng, Yinghui Wang*, Shuyan Song, Hongjie Zhang, Multi-enzyme co-expressed nanomedicine for anti-metastasis tumor therapy by up-regulating cellular oxidative stress and depleting cholesterol, Adv. Mater. 2024, 36, 2307752. (ESI高被引论文)

11. Rui Niu, Yang Liu*, Bo Xu, Ruiping Deng, Shijie Zhou, Yue Cao, Wanying Li, Hao Zhang, Haiyang Zheng, Shuyan Song, Yinghui Wang*, Hongjie Zhang*, Programed targeting pyruvate metabolism therapy-amplified single-atom nanozyme-activate pyroptosis for immunotherapy, Adv. Mater. 2024, 36, 2312124. (ESI高被引论文)

12. Yang Liu†, Bo Wang†, Junjie Zhu, Xinnan Xu, Bin Zhou, Yang Yang*, Single-atom nanozyme with asymmetric electron distribution for tumor catalytic therapy by disrupting tumor redox and energy metabolism homeostasis, Adv. Mater. 2023, 35, 2208512. (ESI高被引论文)

13. Na Yin, Yinghui Wang*, Yang Liu*, Rui Niu, Shuai Zhang, Yue Cao, Zhijia Lv, Shuyan Song, Xiaogang Liu, Hongjie Zhang*, A cholesterol metabolic regulated hydrogen-bonded organic framework (HOF)-based biotuner for antibody non-dependent immunotherapy tailored for glioblastoma. Adv. Mater. 2023, 35, 2303567.

14. Shuai Zhang, Yang Liu*, Yue Cao, Songtao Zhang, Jian Sun*, Yinghui Wang*, Shuyan Song, Hongjie Zhang*, Targeting the microenvironment of vulnerable atherosclerotic plaques: An emerging diagnosis and therapy strategy for atherosclerosis, Adv. Mater. 2022, 34, 2110660.

15. Yang Liu, Yinghui Wang*, Shuyan Song, Hongjie Zhang*, Tumor diagnosis and therapy mediated by metal phosphorus-based nanomaterials, Adv. Mater. 2021, 33, 2103936.